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Published on: March 23, 2022
Ex Vivo Tracking of Endogenous CO with a Ruthenium(II) Complex
Cristina de la Torre1,2,3, Anita Toscani4, Cristina Marín-Hernández1,2,3
1Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València, Universitat de València , 46022 Valencia, Spain.
Abstract:
A two-photon fluorescent probe based on a ruthenium(II) vinyl complex is capable of selectively detecting carbon monoxide in cells and ex vivo using mice with a subcutaneous air pouch as a model for inflammation. This probe combines highly selective and sensitive ex vivo detection of endogenous CO in a realistic model with facile, inexpensive synthesis, and displays many advantages over the widely used palladium-based systems.

