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Decrease in scale invariance of activity fluctuations with aging and in patients with suprasellar tumors.

S D Joustra1, C Gu2,3, J H T Rohling2

  • 1a Center for Endocrine Tumors Leiden, Department of Medicine, Division of Endocrinology , Leiden University Medical Center , Leiden , The Netherlands.

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|November 29, 2017
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Summary
This summary is machine-generated.

Scale invariance of motor activity fluctuations is reduced in healthy adults over 33 and significantly more so in patients with suprasellar tumors impacting the suprachiasmatic nucleus (SCN). This suggests SCN function is crucial for maintaining these complex patterns.

Keywords:
Circadian rhythmicitycraniopharyngiomadetrended fluctuation analysisnonfunctioning pituitary macroadenomascale invariancesuprachiasmatic nucleus

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Area of Science:

  • Neuroscience
  • Chronobiology
  • Human Physiology

Background:

  • Healthy human motor activity exhibits scale-invariant fluctuations across various timescales.
  • The suprachiasmatic nucleus (SCN) is essential for maintaining these scale-invariant motor activity patterns.
  • Suprasellar tumors can compress and potentially impair SCN function.

Purpose of the Study:

  • To investigate if scale invariance of motor activity is degraded in patients with suprasellar tumors.
  • To examine the influence of age and gender on scale invariance in healthy individuals.
  • To compare motor activity patterns between patients and healthy controls.

Main Methods:

  • Actigraphy was used to record spontaneous wrist locomotor activity over 7 days in 68 patients with pituitary macroadenoma, 22 with craniopharyngioma, and 72 healthy controls.
  • Detrended fluctuation analysis (DFA) assessed correlations across timescales from minutes to 24 hours.
  • Statistical analysis compared scale invariance between patient groups and controls, and explored age and gender effects.

Main Results:

  • Scale invariance was present for timescales < 1.5 hours, becoming more random between 1.5-10 hours in all subjects.
  • Patients with suprasellar tumors showed a greater reduction in correlations at 1.5-10 hours compared to controls.
  • Healthy subjects >33 years exhibited attenuated scale invariance, particularly at 1.5-10 hours, with increased regularity noted between 10-24 hours, associated with age.

Conclusions:

  • Scale invariance of motor activity is degraded in healthy individuals over 33 years of age.
  • Suprasellar tumors further degrade scale invariance, highlighting the SCN's role in maintaining these patterns.
  • Age and SCN integrity are critical factors influencing the scale-invariant nature of human motor activity.