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Marathon running increases circulating endothelial- and thrombocyte-derived microparticles.

Viktoria Schwarz1, Philip Düsing1, Thomas Liman2

  • 11 Department for Internal Medicine III, Cardiology, Angiology and Intensive Care Medicine, Saarland University, Homburg/Saar, Germany.

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|November 30, 2017
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Summary
This summary is machine-generated.

Marathon running acutely increases circulating apoptotic endothelial- and thrombocyte-derived microparticles, indicating a pro-thrombotic and pro-inflammatory state. These microparticles may signal exercise-induced vascular damage and potential cardiovascular risks.

Keywords:
Microparticlesendothelial dysfunctioninflammationmarathonphysical activity

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Area of Science:

  • Cardiovascular Physiology
  • Exercise Science
  • Biomarkers

Background:

  • Acute vascular effects of high-intensity exercise are not fully understood.
  • Circulating microparticles serve as cellular markers for vascular activation and damage.
  • Marathon running represents a significant physiological stressor.

Purpose of the Study:

  • To characterize acute changes in circulating microparticles following marathon running.
  • To investigate the association between microparticle levels and vascular activation/damage markers.
  • To explore the potential of microparticles as indicators of post-exertional cardiovascular complications.

Main Methods:

  • Analysis of endothelial-, platelet-, leukocyte-, and monocyte-derived microparticles in 99 marathon runners.
  • Blood samples collected pre-run, immediately post-run, and two days post-run.
  • Measurement of Troponin T levels as a marker of cardiac stress.

Main Results:

  • Marathon running significantly increased endothelial- and thrombocyte-derived microparticles, particularly apoptotic forms.
  • Leukocyte and monocyte counts initially increased but monocyte- and leukocyte-derived microparticles decreased post-run.
  • Troponin T levels elevated immediately post-marathon, returning to baseline within two days.

Conclusions:

  • Marathon running induces an acute pro-thrombotic and pro-inflammatory state, evidenced by increased apoptotic microparticles.
  • Exercise-induced vascular damage, reflected by microparticles, may contribute to cardiovascular complications.
  • Microparticles warrant further investigation as biomarkers for identifying individuals at risk of exercise-related cardiovascular events.