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Results from the post-exposure prophylaxis pilot program (P-QUAD) demonstration project in Los Angeles County
Matthew R Beymer1,2, Ryan M Kofron3, Chi-Hong Tseng4
11 Los Angeles LGBT Center, Los Angeles, CA, USA.
Post-exposure prophylaxis (PEP) shows promise for HIV prevention in high-risk groups. A pilot program found a low failure rate, suggesting a need for wider PEP access and funding.
Area of Science:
- Public Health
- Infectious Disease Prevention
- HIV/AIDS Research
Background:
- Post-exposure prophylaxis (PEP) is an under-utilized HIV prevention strategy.
- High-risk populations can benefit from accessible PEP services.
Purpose of the Study:
- To evaluate the effectiveness and utilization of a pilot PEP program.
- To assess PEP efficacy in a real-world clinical setting.
Main Methods:
- A pilot PEP program was implemented in two Los Angeles County clinics from March 2010 to June 2011.
- 267 individuals received PEP, primarily men who have sex with men (84%).
- Regimens typically included a three-drug antiretroviral therapy.
Main Results:
- 64% of PEP courses were followed for at least 12 weeks.
- Seven individuals seroconverted during the study period.
- Six of the seven seroconversions were linked to subsequent HIV re-exposure.
Conclusions:
- The low rate of PEP failure indicates its effectiveness in preventing HIV transmission.
- Expanded funding and access to PEP are recommended for broader implementation.
- PEP is a viable and effective HIV prevention tool for at-risk populations.
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