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Related Experiment Video

Updated: Feb 18, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
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Interleukin-6 upregulates SOX18 expression in osteosarcoma.

Zhong Wu1, Weizhi Yang1, Junjian Liu1

  • 1Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.

Oncotargets and Therapy
|November 30, 2017
PubMed
Summary

Interleukin-6 (IL-6) may regulate SOX18 in osteosarcoma, impacting cell proliferation and apoptosis. This study explores the IL-6 and SOX18 relationship in osteosarcoma tissues and cell lines.

Keywords:
IL-6SOX18apoptosisosteosarcomaproliferation

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Area of Science:

  • Oncology
  • Molecular Biology
  • Gene Regulation

Background:

  • SOX18 acts as a potential oncogene in osteosarcoma, influencing cell proliferation and metastasis.
  • Interleukin-6 (IL-6) signaling, particularly via JAK2/STAT3, is crucial for carcinoma cell growth.

Purpose of the Study:

  • To investigate the correlation between IL-6 and SOX18 in osteosarcoma.
  • To determine if IL-6 influences SOX18 expression and function in osteosarcoma cells.

Main Methods:

  • Assessed protein and mRNA expression using Western blot and real-time PCR.
  • Evaluated cell proliferation and apoptosis via Cell Counting Kit-8 assay and flow cytometry.

Main Results:

  • SOX18, IL-6, and p-STAT3 were upregulated in osteosarcoma compared to bone cyst tissues.
  • IL-6 stimulation dose-dependently increased SOX18 mRNA and protein levels in osteosarcoma cell lines.
  • IL-6 reversed the effects of SOX18 knockdown on osteosarcoma cell proliferation and apoptosis.

Conclusions:

  • IL-6 appears to be an upstream regulator of SOX18 in osteosarcoma.
  • Findings suggest a novel regulatory pathway involving IL-6 and SOX18 in osteosarcoma progression.