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Rhabdomyolysis with different etiologies in childhood

Demet Alaygut1, Meral Torun Bayram2, Belde Kasap2

  • 1Department of Pediatric Nephrology, Dokuz Eylul University Faculty of Medicine, 35340 İnciralti İzmir, Turkey. demet.alaygut@deu.edu.tr.

World Journal of Clinical Pediatrics
|November 30, 2017
PubMed

Insights

This study reviewed eight pediatric rhabdomyolysis cases, identifying infection, physical activity, and licorice as key triggers. Differentiating recurrent from sporadic cases is crucial for appropriate pediatric rhabdomyolysis management.

Area of Science:

  • Pediatric Nephrology
  • Neurology
  • Genetics

Background:

  • Rhabdomyolysis in children presents with diverse etiologies and clinical manifestations.
  • Prompt diagnosis and management are essential to prevent complications like acute kidney injury.

Purpose of the Study:

  • To investigate the various causes and treatment strategies for rhabdomyolysis in pediatric patients.
  • To analyze clinical data from pediatric rhabdomyolysis cases to identify common triggers and outcomes.

Main Methods:

  • Retrospective evaluation of eight pediatric rhabdomyolysis cases.
  • Analysis included patient demographics, symptoms, physical findings, provocative factors, laboratory results, and diagnoses.

Main Results:

  • Infection (pneumonia) and excessive physical activity were primary triggers; excessive licorice consumption was noted in one case.
  • Five patients developed acute kidney injury, with two requiring hemodialysis.
  • Diagnoses included Mycoplasma pneumoniae, sepsis, licorice-induced hypokalemia, genetic disorders (CPT II, VLCAD, congenital muscular dystrophy), and idiopathic paroxysmal rhabdomyolysis.

Conclusions:

  • Distinguishing between sporadic and recurrent rhabdomyolysis is vital.
  • Recurrent pediatric rhabdomyolysis necessitates closer monitoring and attentive management.
Abstract

Keywords:
Acute kidney injuryChildrenEtiologyHemodialysisRhabdomyolysisTreatment

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