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Related Concept Videos

Infertility in Females01:28

Infertility in Females

4.9K
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
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Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

6.4K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
6.4K
Infertility in Males01:23

Infertility in Males

587
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
587
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.8K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.8K
Cancer Therapies02:49

Cancer Therapies

10.2K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.2K

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Related Experiment Video

Updated: Feb 17, 2026

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
08:46

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Published on: September 16, 2021

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Oncofertility in sarcoma patients.

Diana M Lopategui1, Raphael Yechieli1, Ranjith Ramasamy1

  • 1University of Miami Miller School of Medicine, Miami, FL, USA.

Translational Andrology and Urology
|November 30, 2017
PubMed
Summary
This summary is machine-generated.

Fertility preservation is crucial for young sarcoma patients facing gonad damage from cancer treatments. Early counseling and access to established or developing fertility options are essential for survivorship care.

Keywords:
Sarcomafertility preservationoncofertility

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The In ovo CAM-assay as a Xenograft Model for Sarcoma
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Area of Science:

  • Reproductive Medicine
  • Oncology
  • Oncofertility

Background:

  • Sarcoma treatments like chemotherapy and radiation can severely impair fertility in young patients.
  • Infertility significantly impacts adult survivors' quality of life and causes regret.
  • Fertility preservation is vital for adolescent and young adult cancer patients but is underutilized.

Purpose of the Study:

  • To highlight the importance of fertility preservation in sarcoma patients.
  • To review current and emerging fertility preservation methods.
  • To advocate for improved access and implementation of fertility services.

Main Methods:

  • Review of existing fertility preservation techniques.
  • Discussion of novel and developing oncofertility strategies.
  • Analysis of barriers to fertility preservation access.

Main Results:

  • Sperm and oocyte cryopreservation are the current standards of care.
  • Emerging techniques like TESE and in vitro gamete maturation offer future possibilities.
  • Early referral and counseling are critical for successful fertility preservation.

Conclusions:

  • Fertility preservation must be integrated into survivorship care for all reproductive-aged sarcoma patients.
  • Addressing access and cost barriers is a priority for healthcare providers.
  • Continued research into novel therapies and preservation methods is needed.