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Related Experiment Video

Updated: Feb 17, 2026

Fluorescence detection methods for microfluidic droplet platforms
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Embedding liquid lasers within or around aqueous microfluidic droplets.

Lu Zheng1, Min Zhi, Yinthai Chan

  • 1Department of Chemical and Biomolecular Engineering, 3 Engineering Drive 3, National University of Singapore, Singapore 117582, Singapore. saifkhan@nus.edu.sg.

Lab on a Chip
|November 30, 2017
PubMed
Summary
This summary is machine-generated.

Researchers integrated dye-based liquid lasers into microfluidic droplets for advanced sensing. This innovation enables on-drop detection, transforming droplets into self-contained analytical tools for biophysical and biochemical monitoring.

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Area of Science:

  • Microfluidics and Photonics
  • Optical Resonators
  • Biomolecular Sensing

Background:

  • Microfluidic droplets are valuable for compartmentalized reactions and analyses.
  • Integrating active optical components like lasers within droplets presents significant challenges.
  • Whispering-gallery mode (WGM) resonators offer potential for miniaturized laser devices.

Purpose of the Study:

  • To demonstrate the integration of dye-based liquid lasers within aqueous microfluidic droplets.
  • To explore two configurations: lasers dispersed within droplets and lasers forming a shell around droplets.
  • To showcase the application of these integrated lasers for on-drop sensing and analyte detection.

Main Methods:

  • Fabrication of microfluidic devices using glass capillaries.
  • Preparation of dye solutions in benzyl alcohol for liquid lasers.
  • Experimental and theoretical characterization of lasing behavior in droplet systems, utilizing WGM resonances.

Main Results:

  • Successful incorporation of dye-based liquid lasers within and around flowing aqueous microfluidic droplets.
  • Demonstration of stable lasing behavior supported by WGM optical resonances at droplet interfaces.
  • Proof-of-concept application showing embedded lasers enabling on-drop sensing of a model analyte.

Conclusions:

  • The developed method allows for the creation of microfluidic droplets with integrated, spatially segregated laser sources.
  • These laser-equipped droplets function as self-contained analytical platforms for sensitive detection and online monitoring.
  • This approach significantly expands the capabilities of droplet-based microfluidics for biophysical and biochemical applications.