BioGlue® induced granuloma causing symptomatic spinal cord compression: a late complication

Area of Science:

• Neurosurgery
• Biomaterials Science

Background:

• BioGlue® is a widely used surgical adhesive for dural closure in spinal procedures.
• While generally safe, the potential for delayed adverse reactions requires investigation.

Purpose of the Study:

• To report two unique cases of spinal cord compression secondary to BioGlue®-induced granuloma formation.
• To highlight the potential for delayed complications associated with BioGlue® use in spinal surgery.

Main Methods:

• Case report analysis of two patients experiencing adverse events after BioGlue® application.
• Review of clinical presentation, surgical history, and outcomes.

Main Results:

• Two cases of delayed spinal cord compression due to BioGlue®-induced granuloma are presented.
• One patient required surgical intervention for decompression and material removal; the other experienced spontaneous resolution.
• These represent the first reported instances of this specific complication.

Conclusions:

• BioGlue® can elicit a delayed foreign body reaction, forming granulomas that may cause spinal cord compression.
• Judicious use of BioGlue® in spinal surgery is advised to mitigate risks of delayed complications.