BioGlue® induced granuloma causing symptomatic spinal cord compression: a late complication

BioGlue® is an inert, bioadhesive surgical substance commonly used in spinal surgery to aid dural closure. The authors describe two cases in which the use of BioGlue® caused a local reaction culminating in the formation of a granuloma that caused cord compression several years after surgery in one case in which a second operation was required to relieve cord compression and remove the foreign material. In the other case spontaneous resolution occurred. To our knowledge these are the first reports of delayed spinal cord compression secondary to BioGlue®-induced granuloma. We recommend judicious use of this substance.