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Exercise therapy and autonomic function in heart failure patients: a systematic review and meta-analysis
1School of Science and Technology, University of New England, Armidale, NSW, 2351, Australia. mpears23@myune.edu.au.
Heart Failure Reviews
|November 30, 2017
Summary
Exercise training significantly improves autonomic function in heart failure patients. It enhances heart rate recovery and heart rate variability, while reducing muscle sympathetic nerve activity, promoting better cardiovascular health.
Area of Science:
- Cardiology
- Exercise Physiology
- Autonomic Neuroscience
Background:
- Autonomic imbalance is a hallmark of heart failure, linked to poor clinical outcomes.
- Understanding autonomic function is crucial for managing heart failure.
- Exercise training is a key rehabilitation strategy for heart failure patients.
Purpose of the Study:
- To systematically review and meta-analyze the impact of exercise training on autonomic function in heart failure.
- To quantify the effects of exercise on specific autonomic parameters.
- To assess exercise's role in modulating sympathetic and parasympathetic activity in heart failure.
Main Methods:
- Systematic review and meta-analysis of exercise-based rehabilitation trials in heart failure.
- Database searches of PubMed, EMBASE, and Cochrane Trials Register up to March 2017.
- Analysis of exercise training effects on heart rate recovery (HRR), heart rate variability (HRV), and muscle sympathetic nerve activity (MSNA).
Main Results:
- Exercise training significantly increased heart rate recovery at 1 minute (HRR1) by 5.90 bpm.
- Improvements observed in short-term heart rate variability (HRV) parameters: RMSSD (10.44 ms) and HFnu (7.72).
- Statistically significant reductions in muscle sympathetic nerve activity (MSNA) were found, both per minute and per 100 heartbeats.
Conclusions:
- Exercise training demonstrably improves autonomic function in heart failure patients.
- Findings suggest exercise enhances parasympathetic tone and reduces sympathetic overactivity.
- These autonomic improvements underscore exercise's therapeutic potential in heart failure management.
Keywords:
Autonomic functionExerciseHeart failureHeart rate recoveryHeart rate variabilityMuscle sympathetic nerve activityMore Related Videos
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