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Updated: Feb 17, 2026
In Vivo Targeting of Xenografted Human Cancer Cells with Functionalized Fluorescent Silica Nanoparticles in Zebrafish
Published on: May 8, 2020
A redox-responsive mesoporous silica based nanoplatform for in vitro tumor-specific fluorescence imaging and enhanced
Fan Yuan1, Jiang-Lan Li, Han Cheng
1Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China. zeng_xuan@163.com xz-zhang@whu.edu.cn.
Abstract:
In order to obtain an optimal therapeutic effect with minimal systemic toxicity, a redox-responsive mesoporous silica nanoparticle (MSN)-based platform modified with protoporphyrin IX (PpIX)-multifunctional peptides was synthesized as an intelligent theranostic agent carrier. This redox-responsive nanoplatform could release the theranostic agent under a glutathione stimulus, produce fluorescence recovery for tumor-specific fluorescence imaging and provide tumor-enhanced photodynamic therapy.
