Related Experiment Video

Updated: Feb 17, 2026

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
10:05

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

Published on: May 8, 2020

2.3K

An overview about oxidation in clinical practice of skin aging

Silas Arandas Monteiro E Silva1, Bozena Michniak-Kohn2, Gislaine Ricci Leonardi3

  • 1Medicine Department - Universidade Federal de São Paulo (UNIFESP) - São Paulo (SP), Brazil.

Anais Brasileiros De Dermatologia
|November 30, 2017
PubMed

Insights

Topical antioxidants combat skin damage caused by oxidative stress from free radicals. This review highlights evidence supporting their anti-aging benefits, emphasizing the need for comprehensive testing to confirm product effectiveness.

Area of Science:

  • Dermatology
  • Biochemistry
  • Cosmetic Science

Background:

  • Free radicals, highly reactive species, cause cellular damage and oxidative stress.
  • Oxidative stress contributes to skin aging, including wrinkles, spots, and functional impairments like skin cancer.
  • Antioxidants are crucial for neutralizing free radicals and mitigating skin damage.

Purpose of the Study:

  • To review the scientific evidence on the benefits of topical antioxidant application for skin health.
  • To evaluate the efficacy of antioxidants in combating free radical-induced skin aging and damage.
  • To underscore the importance of robust testing for anti-aging product validation.

Main Methods:

  • Literature review of in vitro, ex vivo, and in vivo studies on topical antioxidants.
  • Analysis of studies investigating antioxidant activity and its impact on skin parameters.
  • Evaluation of methodologies used to assess antioxidant product performance.

Main Results:

  • Topical antioxidants demonstrate significant potential in neutralizing free radicals and reducing oxidative stress.
  • Evidence supports the role of antioxidants in mitigating signs of skin aging, such as lines and spots.
  • Various in vitro, ex vivo, and in vivo tests indicate the efficacy of antioxidant treatments.

Conclusions:

  • Topical antioxidants are valuable in managing skin aging and damage induced by oxidative stress.
  • Comprehensive product performance testing is essential to validate the anti-aging claims of antioxidant formulations.
  • Further research should explore a wider range of tests to fully ascertain antioxidant product effectiveness.

More Related Videos

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors09:33

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors

Published on: February 7, 2018

7.9K
Assessment of Oxidative Damage in the Primary Mouse Ocular Surface Cells/Stem Cells in Response to Ultraviolet-C UV-C Damage12:59

Assessment of Oxidative Damage in the Primary Mouse Ocular Surface Cells/Stem Cells in Response to Ultraviolet-C UV-C Damage

Published on: February 15, 2020

6.8K

Related Concept Videos

Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
3.9K
Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
4.6K
Radical Autoxidation01:20

Radical Autoxidation

The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...
3.3K
Oxidation of Phenols to Quinones01:17

Oxidation of Phenols to Quinones

In the presence of oxidizing agents, phenols are oxidized to quinones. Quinones can be easily reduced back to phenols using mild reducing agents. The electron-donating hydroxyl group enhances the reactivity of the aromatic ring, enabling oxidation of the ring even in the absence of an α hydrogen.
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...
4.9K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.8K
Phase I Oxidative Reactions: Overview01:19

Phase I Oxidative Reactions: Overview

Phase I biotransformation, or functionalization, is a crucial chemical process that converts drugs and other xenobiotics into more water-soluble forms, facilitating expulsion from the body. It involves oxidative, reductive, and hydrolytic reactions that add or unveil polar functional groups on lipophilic substrates. Key players in phase I reactions are the mixed-function oxidases. Situated in liver cell microsomes, these enzymes predominantly carry out drug metabolism. They require molecular...
845