Related Experiment Video

Updated: Feb 17, 2026

Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal
08:00

Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal

Published on: October 11, 2019

8.0K

The OncoPPi Portal: an integrative resource to explore and prioritize protein-protein interactions for cancer target

Andrei A Ivanov1,2, Brian Revennaugh1, Lauren Rusnak1

  • 1Department of Pharmacology and Emory Chemical Biology Discovery Center, Emory University School of Medicine.

Bioinformatics (Oxford, England)
|November 30, 2017
PubMed
Abstract

Insights

The OncoPPi Portal offers a new resource for cancer research, providing experimentally detected protein-protein interactions (PPIs) to identify novel drug targets and advance cancer therapies.

Area of Science:

  • Oncology
  • Bioinformatics
  • Drug Discovery

Background:

  • Cancer genomics aims to identify genetic alterations driving tumor development.
  • Cancer-specific protein-protein interactions (PPIs) are promising druggable targets.
  • Limited resources exist for exploring oncogenic PPI networks.

Purpose of the Study:

  • To present the OncoPPi Portal, an interactive web resource for cancer-focused PPIs.
  • To facilitate the prioritization of PPIs for biological studies and drug development.
  • To enable the discovery of new tumor dependencies and therapeutic strategies.

Main Methods:

  • Developed a high-throughput screening platform for detecting cancer-associated PPIs in cancer cells.
  • Integrated network connectivity, genomic alteration mutual exclusivity, and cellular co-localization analyses.
  • Estimated PPI essentiality to assess the impact of PPI disruption on cancer cell proliferation.

Main Results:

  • The OncoPPi Portal provides access to a high-quality, cancer-focused network of experimentally detected PPIs.
  • The resource facilitates the prioritization of PPIs through integrated analyses.
  • Connecting the OncoPPi network with drug information aids in identifying new therapeutic targets.

Conclusions:

  • The OncoPPi Portal serves as a valuable resource for the cancer research community.
  • It supports the discovery of novel cancer targets and aids in therapeutic development.
  • The portal facilitates the interrogation of previously undruggable targets.

More Related Videos

Mapping Dysfunctional Protein-Protein Interactions in Disease09:39

Mapping Dysfunctional Protein-Protein Interactions in Disease

Published on: October 24, 2025

909
Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer09:40

Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer

Published on: August 2, 2024

3.2K

Related Concept Videos

Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
14.8K
Protein-Protein Interfaces02:04

Protein-Protein Interfaces

4.5K
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.6K
Protein Networks02:26

Protein Networks

2.9K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.9K
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
11.5K