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The Genetic Basis of Psoriasis.
1Department of Medical and Molecular Genetics, School of Basic and Biomedical Sciences, King's College London, London SE1 9RT, UK. francesca.capon@kcl.ac.uk.
International Journal of Molecular Sciences
|December 1, 2017
Summary
Genetic studies reveal psoriasis involves inherited factors and environmental triggers. Key findings point to Th17 cell pathways and interleukin-36 cytokines as crucial targets for new, effective biologic therapies.
Area of Science:
- Immunodermatology
- Human Genetics
- Translational Medicine
Background:
- Psoriasis is a complex, multifactorial skin disease influenced by genetic predisposition and environmental factors.
- Recent advancements in genetic technologies have significantly improved our understanding of psoriasis pathogenesis.
- Genome-wide association studies (GWAS) have identified numerous susceptibility regions associated with the condition.
Purpose of the Study:
- To review recent genetic discoveries in psoriasis.
- To highlight the role of Th17 cell activation and interleukin-36 cytokines in disease development.
- To discuss the therapeutic potential of genetic insights for novel biologic treatments.
Main Methods:
- Review of genome-wide association studies (GWAS) for psoriasis susceptibility regions.
- Analysis of studies investigating rare genetic variants in psoriasis.
- Examination of research on Th17 cell pathways and interleukin-36 (IL-36) cytokine function.
Main Results:
- Over 60 psoriasis susceptibility regions have been identified through GWAS.
- Genes involved in Th17 cell activation are critically implicated in psoriasis.
- Interleukin-36 (IL-36) cytokines are identified as key amplifiers of Th17 signaling.
Conclusions:
- Genetic studies provide crucial insights into psoriasis pathophysiology.
- The Th17 pathway and IL-36 cytokines represent promising therapeutic targets.
- These discoveries underscore the translational potential of genetic research for developing effective psoriasis treatments.
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