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Plasmonic Optical Fiber-Grating Immunosensing: A Review.

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Area of Science:

  • Optoelectronics
  • Biosensing
  • Nanotechnology

Background:

  • Plasmonic immunosensors utilize noble metals and bioreceptors for analyte detection via affinity mechanisms.
  • Optical fiber configurations offer miniaturized, remote-operable alternatives to traditional prism-based surface plasmon (SP) excitation.
  • Metal-coated fiber gratings are emerging as advanced platforms for SP generation, particularly within the telecommunication wavelength window.

Purpose of the Study:

  • To review recent advancements in plasmonic immunosensors based on metal-coated fiber gratings.
  • To highlight the capabilities of various grating types (uniform, tilted, eccentric, long-period) for surface plasmon resonance (SPR) excitation.
  • To discuss the application potential of these fiber optic sensors in sensitive analyte detection and in vivo diagnostics.

Main Methods:

  • Fabrication of metal-coated fiber gratings (uniform, tilted, eccentric, long-period) within optical fibers.
  • Utilizing core-guided light outcoupling to excite surface plasmons (SPs) at the metal-dielectric interface.
  • Employing cost-effective, high-resolution interrogators for sensitive signal detection.

Main Results:

  • Metal-coated fiber gratings facilitate SP generation across various wavelengths, including the telecommunication window.
  • These configurations achieve high sensitivity and low limits of detection in immunosensing applications.
  • The sensors demonstrate effectiveness with minute analyte volumes and hold promise for in vivo diagnostic applications.

Conclusions:

  • Metal-coated fiber gratings represent a significant advancement in optical fiber-based plasmonic immunosensors.
  • These sensors offer a robust platform for sensitive and specific analyte detection.
  • Future applications may extend to real-time, in vivo monitoring and diagnostics.