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Metabolites Produced by an Endophytic Phomopsis sp. and Their Anti-TMV Activity

Qing-Wei Tan1,2, Pei-Hua Fang3, Jian-Cheng Ni4

  • 1Key Laboratory of Bio-Pesticide and Chemistry-Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou 350002, China. tanqingwei@fafu.edu.cn.

Molecules (Basel, Switzerland)
|December 1, 2017
PubMed

Insights

An endophytic fungus produced novel compounds, including cytosporone U, which effectively inhibited Tobacco mosaic virus (TMV). Exopolysaccharides also showed strong anti-viral activity against TMV infection.

Area of Science:

  • Mycology
  • Plant Pathology
  • Natural Product Chemistry

Background:

  • Endophytic fungi are a rich source of bioactive metabolites.
  • Phytopathogenic viruses cause significant crop losses worldwide.
  • Developing novel antiviral agents is crucial for sustainable agriculture.

Purpose of the Study:

  • To isolate and identify secondary metabolites from the endophytic fungus *Phomopsis* sp. FJBR-11.
  • To evaluate the antiviral activity of the isolated compounds and exopolysaccharides against Tobacco mosaic virus (TMV).

Main Methods:

  • Phylogenetic analysis for fungal identification.
  • Fermentation and isolation of fungal metabolites.
  • Bioassay for antiviral activity against TMV.

Main Results:

  • Six compounds were identified: dothiorelones A-C, H, and cytosporones C and U.
  • Cytosporone U demonstrated potent inhibitory activity against TMV.
  • Crude and purified exopolysaccharides exhibited strong TMV inhibitory effects.

Conclusions:

  • The endophytic fungus *Phomopsis* sp. FJBR-11 produces bioactive compounds with antiviral properties.
  • Cytosporone U and exopolysaccharides are potential candidates for TMV control strategies.
Keywords:
PhomopsisTobacco mosaic viruscytosporonedothiorelone

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