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Limitations of flow cytometric DNA analysis for the diagnosis of bladder cancer
M A Boileau1, D Swartz, K L Schmidt
1Department of Surgery, Medical School, University of Texas Health Science Center-Houston.
Journal of Surgical Oncology
|March 1, 1989
Abstract:
Flow cytometric analysis was done on exfoliated urothelial cells from 11 control patients and 31 patients with transitional cell carcinoma: 9 grade I, 11 grade II, and 11 grade III. The determination of aneuploidy by DNA analysis did not provide identification of low-grade tumor cells. Other flow cytometric parameters of cellular change such as cell size, nuclear size, nuclear/cytoplasmic ratio, or cell refractivity may provide better identification of low-grade lesions.