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MiRNA-210: A Current Overview

Alberto Bavelloni1, Giulia Ramazzotti2, Alessandro Poli3,4

  • 1SC Laboratory of Musculoskeletal Cell Biology, Rizzoli Orthopedic Institute (IOR), Bologna, Italy.

Anticancer Research
|December 1, 2017
PubMed

Insights

MicroRNAs (miRNAs) regulate gene expression and are implicated in cancer. This review focuses on microRNA-210 (miR-210), a key hypoxia-induced miRNA involved in various cellular processes and diseases.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression post-transcriptionally.
  • Emerging evidence links miRNAs to cancer development and metastasis.
  • Hypoxia significantly impacts cellular processes, often involving specific miRNA induction.

Purpose of the Study:

  • To provide a comprehensive overview of microRNA-210 (miR-210) functions.
  • To summarize the role of miR-210 in biological processes and diseases.
  • To highlight miR-210 as a key hypoxia-responsive miRNA.

Main Methods:

  • Literature review of existing research on miR-210.
  • Analysis of studies identifying miR-210 targets.
  • Synthesis of data on miR-210's involvement in cellular pathways.

Main Results:

  • miR-210 is a major miRNA induced by hypoxia.
  • Identified targets of miR-210 indicate roles in mitochondrial metabolism, angiogenesis, DNA damage response, proliferation, and apoptosis.
  • miR-210 is implicated in various disease pathologies.

Conclusions:

  • miR-210 plays a critical role in cellular responses to hypoxia.
  • Dysregulation of miR-210 contributes to tumorigenesis and disease progression.
  • Further research into miR-210 mechanisms and therapeutic potential is warranted.
Keywords:
cancerdiseasehypoxiamiR-210microRNAreview

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