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Primary Urinary Tract Lymphoma: Rare but Aggressive.
Konstantinos Lontos1, Anastasia Tsagianni2, Pavlos Msaouel3
1Division of Hematology/Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, U.S.A. lontosk@upmc.edu.
Anticancer Research
|December 1, 2017
Summary
Primary urinary tract lymphoma (PUTL) is rare, with DLBCL being the most common type. Survival rates have not improved, indicating a need for new treatments for this uncommon cancer.
Area of Science:
- Oncology
- Epidemiology
- Urologic Oncology
Background:
- Primary urinary tract lymphoma (PUTL) is an exceptionally rare malignancy.
- Limited case reports exist, highlighting a gap in understanding its epidemiology and outcomes.
Purpose of the Study:
- To analyze the largest population-based cohort of PUTL patients to date.
- To identify prognostic factors and compare outcomes of PUTL with nodal lymphoma.
Main Methods:
- Utilized the Surveillance, Epidemiology, and End Results (SEER) database for 1,264 PUTL patients (1983-2013).
- Employed Kaplan-Meier curves and multivariable regression for survival analysis.
- Compared kidney vs. bladder lymphoma and PUTL DLBCL vs. nodal DLBCL.
Main Results:
- PUTL incidence is 1 per million annually; DLBCL is the predominant histology.
- Five-year overall and cancer-specific survival rates are 49% and 58%, respectively.
- Poor prognostic factors include DLBCL histology, male gender, advanced stage, and older age; surgery may be beneficial.
Conclusions:
- This study represents the largest population-based analysis of PUTL.
- Survival has not improved with modern therapies, underscoring the urgent need for novel treatment strategies.
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