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Moderate-to-severe atopic dermatitis patients show increases in serum C-reactive protein levels, correlating with

Anjali S Vekaria1, Patrick M Brunner2, Ahmad I Aleisa1

  • 1Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

F1000Research
|December 5, 2017
PubMed

Insights

C-reactive protein (CRP) is elevated in moderate-to-severe atopic dermatitis (AD), correlating with disease severity and indicating increased cardiovascular risk in these patients.

Area of Science:

  • Dermatology
  • Immunology
  • Cardiovascular Health

Background:

  • Atopic dermatitis (AD) is a common chronic inflammatory skin condition with systemic implications.
  • Emerging evidence suggests a link between systemic inflammation in AD and increased cardiovascular disease risk.

Purpose of the Study:

  • To investigate C-reactive protein (CRP) levels in patients with moderate-to-severe AD.
  • To assess the correlation between CRP levels and clinical disease severity (SCORAD, BSA).
  • To evaluate CRP as a potential marker for systemic inflammation and cardiovascular risk in AD.

Main Methods:

  • Serum CRP levels were measured in 59 patients with moderate-to-severe AD and compared to 118 matched healthy controls from NHANES.
  • Clinical severity was assessed using SCORing of Atopic Dermatitis (SCORAD) and body surface area (BSA).
  • Correlations between CRP, SCORAD, BSA, IgE, and LDH levels were analyzed.

Main Results:

  • AD patients exhibited significantly higher serum CRP levels compared to controls (p=0.001).
  • Elevated CRP levels (>0.3mg/dl) were observed in 52.5% of AD patients, suggesting high cardiovascular risk.
  • CRP levels showed significant positive correlations with both SCORAD (r=0.427, p=0.0008) and BSA (r=0.407, p=0.0015).
  • Elevated IgE and LDH levels were noted in AD patients, but correlations with disease severity and CRP were weak or non-significant.

Conclusions:

  • C-reactive protein (CRP) is a reliable marker for disease severity in moderate-to-severe atopic dermatitis.
  • The findings support the concept of AD as a systemic disease with associated chronic inflammation.
  • Elevated CRP in AD patients highlights potential cardiovascular risks that warrant further investigation.

Keywords:
Atopic dermatitisC-reactive proteindisease biomarkersystemic inflammation

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