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Measuring Central Retinal Sensitivity Using Microperimetry.

Mays Talib1, Jasleen K Jolly2,3, Camiel J F Boon4,5

  • 1Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands.

Methods in Molecular Biology (Clifton, N.J.)
|December 1, 2017
PubMed
Summary
This summary is machine-generated.

Microperimetry assesses central macula sensitivity and fixation, aiding gene therapy trials and treatment planning. This review details performing the Macular Integrity Assessment (MAIA) microperimetry for retinal function evaluation.

Keywords:
MAIAMicroperimetryRetinal sensitivity

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Area of Science:

  • Ophthalmology
  • Retinal Imaging
  • Visual Function Testing

Background:

  • Microperimetry is crucial for assessing central macula sensitivity and fixation.
  • It integrates structural and functional retinal data, even with unstable fixation.
  • Gene therapy trials increasingly use microperimetry to measure retinal function changes.

Purpose of the Study:

  • To review the essential steps for performing Macular Integrity Assessment (MAIA) microperimetry.
  • To highlight the utility of microperimetry in retinal treatment planning and evaluating therapeutic windows.
  • To provide a guide for consistent and accurate MAIA microperimetry execution.

Main Methods:

  • Detailed procedural review of MAIA microperimetry.
  • Focus on key steps for accurate sensitivity and fixation analysis.
  • Emphasis on combining structural and functional retinal information.

Main Results:

  • The review outlines the practical execution of MAIA microperimetry.
  • It establishes MAIA as a key tool for assessing retinal function.
  • The method facilitates objective outcome measurement in clinical trials.

Conclusions:

  • MAIA microperimetry is a valuable tool for detailed retinal function assessment.
  • Its application is vital for monitoring gene therapy efficacy and guiding treatment strategies.
  • Standardized performance of MAIA ensures reliable data for clinical decision-making.