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Investigating Small-Molecule Ligand Binding to G Protein-Coupled Receptors with Biased or Unbiased Molecular Dynamics

Kristen A Marino1, Marta Filizola2

  • 1Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1677, New York, NY, 10029, USA.

Methods in Molecular Biology (Clifton, N.J.)
|December 1, 2017
PubMed

Keywords:
Allosteric communicationEnhanced-sampling methodsGPCRsInteraction fingerprintsLigand bindingMolecular dynamicsSmall-molecule drugs

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