Rabies.

Area of Science:

• Zoonotic diseases
• Virology
• Public Health

Background:

• Rabies is a neglected tropical disease causing tens of thousands of annual deaths, primarily in Africa and Asia.
• It is a zoonotic viral infection transmitted via saliva, with dogs being the main reservoir, responsible for over 99% of human cases.
• Once clinical symptoms appear, rabies is almost invariably fatal.

Purpose of the Study:

• To summarize the epidemiology and prevention strategies for rabies.
• To highlight the importance of a multifaceted approach for human rabies eradication.
• To support the World Health Organization's goal of zero human rabies deaths by 2030.

Main Methods:

• Review of existing literature on rabies transmission, pathogenesis, and prevention.
• Analysis of epidemiological data on rabies cases and mortality.
• Synthesis of current strategies for disease control and eradication.

Main Results:

• Dog bites are the primary route of human rabies transmission (>99%).
• Primary prevention focuses on canine vaccination to reduce the reservoir.
• Post-exposure prophylaxis (wound care, immunoglobulin, vaccination) is critical after exposure.

Conclusions:

• Human rabies eradication requires integrated strategies including government support, public awareness, human vaccination, and robust canine rabies control.
• Achieving zero human rabies cases by 2030 necessitates a concerted global effort focused on dog vaccination and timely post-exposure prophylaxis.