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Soluble Milk Proteins Improve Muscle Mass Recovery after Immobilization-Induced Muscle Atrophy in Old Rats but Do not
1Dominique Dardevet, INRA, Unité de Nutrition Humaine (UNH, UMR 1019), CRNH Auvergne, France, dominique.dardevet@clermont.inra.fr.
Objectives:
Effect of 3 different dairy protein sources on the recovery of muscle function after limb immobilization in old rats.
Design:
Longitudinal animal study.
Setting:
Institut National de la Recherche Agronomique (INRA). The study took part in a laboratory setting.
Intervention:
Old rats were subjected to unilateral hindlimb immobilization for 8 days and then allowed to recover with 3 different dietary proteins: casein, soluble milk proteins or whey proteins for 49 days.
Measurements:
Body weight, muscle mass, muscle fibre size, isometric, isokinetic torque, muscle fatigability and muscle oxidative status were measured before and at the end of the immobilization period and during the recovery period i.e 7, 21, 35 and 49 days post immobilization.
Results:
In contrast to the casein diet, soluble milk proteins and whey proteins were efficient to favor muscle mass recovery after cast immobilization during aging. By contrast, none of the 3 diary proteins was able to improve muscle strength, power and fatigability showing a discrepancy between the recovery of muscle mass and function. However, the soluble milk proteins allowed a better oxidative capacity in skeletal muscle during the rehabilitation period.
Conclusion:
Whey proteins and soluble milk proteins improve muscle mass recovery after immobilization-induced muscle atrophy in old rats but do not allow muscle functional property restoration.
