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Updated: Feb 17, 2026

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
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Targeting Cytokines for Morphine Tolerance: A Narrative Review

Dai-Qiang Liu1,2, Ya-Qun Zhou1,2, Feng Gao1,2

  • 1Anesthesiology Institute, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Current Neuropharmacology
|December 1, 2017
PubMed
Summary

Cytokines and chemokines increase with morphine tolerance. Targeting these molecules, like interleukin 10, may help manage pain therapy side effects.

Keywords:
Morphine toleranceanti-inflammatory cytokineschemokinesglial cellspainpro-inflammatory cytokines.

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