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Related Concept Videos

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

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Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
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Bioavailability Enhancement: Drug Solubility Enhancement01:16

Bioavailability Enhancement: Drug Solubility Enhancement

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Body:Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
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Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

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Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
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Factors Influencing Drug Absorption: Drug Dissolution01:27

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The pharmacokinetic journey of drugs from solid oral dosage forms into systemic circulation is multifaceted. It begins with disintegration, a prerequisite ensuring a solid dosage form's subdivision into minute particles. Dissolution occurs next as these granulated entities solubilize in gastrointestinal fluids. This solubilization is crucial for the succeeding stage, permeation, which describes the traversal of the drug across the intestinal membrane and its subsequent entry into the blood...
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Drug Dissolution: Requirements and Profile Comparison01:14

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The acceptance criteria for dissolution profile data are anchored in Q values, representing the percentage of drug dissolved within a specified period. This assessment unfolds in three stages:First Stage: The test passes if all six drug dosage units are equal to or greater than Q plus 5%; otherwise, the sample proceeds to the second stage.Second Stage: The average of twelve units must be equal to or greater than Q, with no unit falling below Q - 15% to pass; if not, it progresses to the final...
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Related Experiment Video

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Formation of Dispersible Taohong Siwu Tablets
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Furosemide - Soluplus® Solid Dispersion: Development and Characterization.

Rammani Prasad1, Praveen Radhakrishnan2, Sandeep K Singh1

  • 1Department of Pharmaceutical Science and Technology, Birla Institute of Technology, Mesra, Ranchi, India.

Recent Patents on Drug Delivery & Formulation
|December 1, 2017
PubMed
Summary
This summary is machine-generated.

This study developed stable solid dispersions of furosemide with Soluplus® to improve drug dissolution. The fusion method yielded faster drug release compared to solvent evaporation, with a 1:10 drug to carrier ratio being optimal.

Keywords:
Furosemidedissolutiongibbs free energyphase solubilitysolid dispersionsoluplus.

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Soluplus® is a patented excipient known to enhance drug dissolution.
  • Previous research indicates its potential for modulating active pharmaceutical ingredient (API) characteristics.

Purpose of the Study:

  • To investigate the formation of a stable solid solution of furosemide with Soluplus®.
  • To enhance the dissolution properties of furosemide using Soluplus® as a carrier.

Main Methods:

  • Solid dispersions of furosemide and Soluplus® were prepared using solvent evaporation and fusion techniques.
  • Physicochemical characterization involved FTIR, TGA, DTA, and SEM.
  • Drug release studies were conducted using a USP type II dissolution apparatus.

Main Results:

  • FTIR confirmed no chemical interactions between furosemide and Soluplus®.
  • TGA and DTA provided evidence for solid solution formation.
  • SEM revealed the absence of furosemide crystals in the solid dispersion.
  • Enhanced furosemide dissolution was observed, with a 1:10 drug-to-carrier ratio proving most effective.

Conclusions:

  • Solid dispersions significantly enhance furosemide dissolution.
  • The fusion method resulted in superior drug release compared to the solvent evaporation method.