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Asthma-I: Introduction01:29

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma Detection Research Based on Voice Signal Processing and Machine Learning
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Asthma: personalized and precision medicine.

Giorgio W Canonica1,2, Matteo Ferrando3, Ilaria Baiardini3

  • 1Department of Biomedical Sciences, Humanitas University.

Current Opinion in Allergy and Clinical Immunology
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Summary

Severe asthma management is shifting from broad treatments to personalized, endotype-driven therapies. This approach uses biomarkers and omics sciences for tailored treatments, aiming for better patient outcomes and reduced exacerbations.

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Area of Science:

  • Pulmonology
  • Biomarker Discovery
  • Personalized Medicine

Background:

  • Traditional severe asthma management relied on a 'blockbuster approach'.
  • Advances in understanding asthma phenotypes and endotypes are crucial.
  • Biomarker identification enables a more targeted therapeutic strategy.

Purpose of the Study:

  • To review the evolution of severe asthma management.
  • To highlight the transition towards personalized, endotype-driven therapies.
  • To discuss the role of omics sciences in this transition.

Main Methods:

  • Review of current literature on severe asthma management.
  • Analysis of biomarker-driven approaches.
  • Exploration of omics sciences contributions (genomics, proteomics, etc.).

Main Results:

  • Severe asthma characterization now includes phenotypes and endotypes.
  • Distinction between personalized and precision medicine clarified.
  • Omics sciences provide concrete data for endotype identification.

Conclusions:

  • Personalized therapeutic strategies improve patient selection for severe asthma.
  • Endotype-driven treatments lead to more precise interventions.
  • This approach promises reduced exacerbations, improved symptoms, and enhanced quality of life.