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Related Experiment Videos

Body composition changes in the subtotally nephrectomized rat fed differing dietary proteins.

A J Williams1, J Walls

  • 1Department of Nephrology, Leicester General Hospital, UK.

Nephron
|January 1, 1989
PubMed
Summary

Altered body composition in chronic kidney disease (CKD) is linked to impaired renal function, not poor nutrient intake. Studies show reduced body fat and increased body water in nephrectomized rats, supporting this conclusion.

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Area of Science:

  • Nephrology
  • Metabolic Research

Background:

  • Chronic uraemia is associated with changes in body composition.
  • The cause of these changes, whether poor nutrient intake or impaired renal function, remains unclear.

Purpose of the Study:

  • To investigate whether altered body composition in uraemia results from impaired renal function or poor nutrient intake.

Main Methods:

  • 31 female Wistar rats underwent subtotal nephrectomy or sham operation.
  • Rats were fed diets containing either 24% casein or 24% soya protein.
  • Inulin clearance, body water, and body fat were measured three months post-operation.

Main Results:

  • Subtotally nephrectomized rats had significantly higher body water and lower body fat compared to controls.

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  • A significant correlation was observed between glomerular filtration rate and body fat content.
  • Dietary protein source did not influence body composition.

    • Conclusions:

    • Altered body composition in uraemia is primarily a consequence of renal dysfunction.
    • Impaired renal function, rather than altered nutrient intake, drives changes in body composition in uraemia.