Related Experiment Video
Updated: Feb 17, 2026

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
Published on: August 12, 2020
Race, Income and Insurance Status Affect Neonatal Sepsis Mortality and Healthcare Resource Utilization
Fredrick J Bohanon1, Omar Nunez Lopez1, Deepak Adhikari1,2
1From the Department of Surgery.
Insights
Socioeconomic factors like insurance status and income significantly increase neonatal sepsis mortality. Addressing these disparities is crucial for reducing infant deaths and improving healthcare resource use in the US.
Area of Science:
- Neonatal Health
- Public Health
- Health Disparities
Background:
- Socioeconomic disparities are known to negatively impact neonatal health outcomes.
- The specific influence of sociodemographic factors on neonatal sepsis mortality remains understudied.
- This research investigates the association between insurance payer status, income, race, and gender with neonatal sepsis outcomes.
Purpose of the Study:
- To examine the impact of sociodemographic disparities on neonatal sepsis mortality.
- To analyze the association between socioeconomic factors and healthcare resource utilization in neonates with sepsis.
- To identify specific societal targets for reducing neonatal sepsis mortality in the United States.
Main Methods:
- Utilized the nationwide Kid's Inpatient Database (2006, 2009, 2012) for a population-based study.
- Included neonates diagnosed with sepsis in the analysis cohort.
- Employed multivariable logistic and linear regression models to assess associations between patient/hospital characteristics and outcomes (mortality, length of stay, hospital costs).
Main Results:
- The study analyzed a weighted sample of 160,677 neonates with sepsis.
- Self-pay status was linked to a 3.26-fold increased mortality risk and reduced length of stay and costs compared to privately insured neonates.
- Lower household income and Black race were also associated with increased mortality and altered healthcare resource utilization, respectively, compared to affluent and White neonates.
Conclusions:
- Identified specific socioeconomic disparities that elevate the risk of death in neonates with sepsis.
- Highlighted how these disparities also influence healthcare resource utilization.
- Provides actionable insights for societal interventions aimed at mitigating neonatal sepsis mortality.
Background:
Socioeconomic disparities negatively impact neonatal health. The influence of sociodemographic disparities on neonatal sepsis is understudied. We examined the association of insurance payer status, income, race and gender on neonatal sepsis mortality and healthcare resource utilization.
Methods:
We used the Kid's Inpatient Database, a nationwide population-based survey from 2006, 2009 and 2012. Neonates diagnosed with sepsis were included in the study. Multivariable logistic regression (mortality) and multivariable linear regression (length of stay and total hospital costs) were constructed to determine the association of patient and hospital characteristics.
Results:
Our study cohort included a weighted sample of 160,677 septic neonates. Several sociodemographic disparities significantly increased mortality. Self-pay patients had increased mortality (odds ratio 3.26 [95% confidence interval: 2.60-4.08]), decreased length of stay (-2.49 ± 0.31 days, P < 0.0001) and total cost (-$5015.50 ± 783.15, P < 0.0001) compared with privately insured neonates. Additionally, low household income increased odds of death compared with the most affluent households (odds ratio 1.19 [95% confidence interval: 1.05-1.35]). Moreover, Black neonates had significantly decreased length of stay (-0.86 ± 0.25, P = 0.0005) compared with White neonates.
Conclusions:
This study identified specific socioeconomic disparities that increased odds of death and increased healthcare resource utilization. Moreover, this study provides specific societal targets to address to reduce neonatal sepsis mortality in the United States.
Related Concept Videos
Bias in Epidemiological Studies
Healthcare Associated Infections II: Preventive Measures
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
Regression Toward the Mean
Pharmacokinetics in Pediatric Patients: Drug Distribution

