Related Experiment Video
Updated: Feb 17, 2026
06:54
Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
Published on: October 27, 2020
14.5K
Crosstalk between TGF-β signaling and epigenome
Jianbo Bai1,2, Qiaoran Xi1
1Ministry of Education Key Laboratory of Protein Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Acta Biochimica Et Biophysica Sinica
|December 1, 2017
Summary
The transforming growth factor beta (TGF-β) signaling pathway regulates gene expression through epigenetic mechanisms. This review highlights how R-SMAD interactions with epigenetic regulators impact development and disease, especially cancer.
Area of Science:
- Molecular Biology
- Developmental Biology
- Epigenetics
Background:
- The transforming growth factor beta (TGF-β) signaling pathway is crucial for embryonic development, tissue homeostasis, immunity, and repair.
- Dysregulation of TGF-β signaling is linked to severe diseases, including cancer.
- Epigenetic regulation plays a key role in mediating cellular responses to TGF-β signaling.
Purpose of the Study:
- To review epigenetic regulatory mechanisms within the TGF-β signaling pathway during mammalian development and disease.
- To elucidate the central role of receptor-activated SMAD (R-SMAD) interactions with epigenetic regulators.
- To discuss the implications of TGF-β signaling and epigenome crosstalk in transcriptional regulation.
Main Methods:
- Literature review focusing on epigenetic mechanisms in TGF-β signaling.
- Analysis of R-SMAD interactions with epigenetic modifiers.
- Examination of studies on mammalian development and disease models.
Main Results:
- TGF-β signaling utilizes epigenetic regulation for cell context-dependent responses.
- R-SMAD proteins recruit epigenetic regulators to modulate gene expression.
- Crosstalk between TGF-β signaling and the epigenome fine-tunes transcription.
Conclusions:
- Epigenetic regulation is integral to TGF-β signaling, influencing development and disease.
- The interaction between R-SMAD and epigenetic regulators is critical for shaping the transcriptome.
- Understanding this crosstalk offers insights into developmental processes and cancer progression.
Related Concept Videos
01:16TGF - β Signaling Pathway
10.6K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
10.6K
01:37Epigenetic Regulation
3.9K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.9K
01:46Epigenetic Regulation
34.0K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
34.0K
02:33Hedgehog Signaling Pathway
10.2K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
10.2K
01:19Interactions Between Signaling Pathways
7.4K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.4K
01:30General Transcription Factors
7.2K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
7.2K