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Transcriptomic analysis of gene expression in mice treated with troxerutin
Yuerong Wang1,2, Shuangshuang Wei1,2, Lintao Chen1,2
1Hainan Key Laboratories of Sustainable Utilization of Tropical Bioresources, Hainan University, Haikou, Hainan, China.
Plos One
|December 1, 2017
Summary
Troxerutin, a bioflavanoid derivative, minimally impacts genome-wide gene transcription in mouse blood cells. This study identified only fifteen differentially expressed genes following troxerutin treatment.
Area of Science:
- Biochemistry
- Molecular Biology
- Genomics
Background:
- Troxerutin, derived from rutin, offers vasoprotective, immune-supportive, anti-inflammatory, and anti-aging benefits.
- The impact of troxerutin on genome-wide gene transcription in blood cells remains uncharacterized.
Purpose of the Study:
- To investigate the effects of troxerutin on genome-wide gene transcription in mouse blood cells.
- To identify specific genes regulated by troxerutin treatment.
Main Methods:
- High-throughput RNA sequencing was utilized to analyze differential gene expression in blood cells (leukocytes, erythrocytes, platelets) from mice treated with troxerutin.
- Bioinformatic analysis using Gene Ontology (GO) was performed on differentially expressed genes.
- Real-time quantitative PCR (Q-PCR) was employed for validation.
Main Results:
- Troxerutin treatment significantly altered the expression of only fifteen genes.
- Of these, 5 genes were upregulated and 10 genes were downregulated.
- Bioinformatic and Q-PCR analyses confirmed these transcriptional changes.
Conclusions:
- Troxerutin exhibits a limited effect on genome-wide gene transcription in mouse blood cells, impacting a small set of genes.
- Further research is needed to elucidate the functional consequences of these specific gene expression changes.
