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Related Concept Videos

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In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
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Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold...
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Related Experiment Video

Updated: Feb 17, 2026

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
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Bisphenol A deteriorates egg quality through HDAC7 suppression.

Bin Liu1, Shasha Zhou2, Chenmin Yang3

  • 1Department of Assisted Reproduction, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, People's Republic of China.

Oncotarget
|December 2, 2017
PubMed
Summary
This summary is machine-generated.

Bisphenol A (BPA) exposure reduces HDAC7 expression, impairing egg quality. Restoring HDAC7 levels partially reverses BPA

Keywords:
HDAC7bisphenol Aegg

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Area of Science:

  • Reproductive Toxicology
  • Epigenetics
  • Endocrinology

Background:

  • Bisphenol A (BPA) is an environmental endocrine disruptor affecting reproductive health.
  • BPA's impact on ovarian follicles and egg quality is known, but mechanisms remain unclear.
  • Ovarian follicle health is crucial for fertilization and pregnancy rates.

Purpose of the Study:

  • To elucidate the underlying mechanisms by which BPA disrupts egg quality.
  • To investigate the role of Histone Deacetylase 7 (HDAC7) in BPA-induced egg quality decline.

Main Methods:

  • Exposure of female mice to Bisphenol A (BPA).
  • Quantification of HDAC7 expression in ovaries and eggs.
  • Analysis of global histone acetylation levels (H3K9 and H4K16) post-BPA exposure.
  • Assessment of egg quality following HDAC7 compensation.

Main Results:

  • BPA treatment led to decreased HDAC7 expression in mouse ovaries and eggs.
  • Global H3K9 and H4K16 acetylation levels increased abnormally after BPA exposure.
  • HDAC7 compensation partially restored normal histone acetylation levels.

Conclusions:

  • BPA exposure deteriorates egg quality by suppressing HDAC7 expression.
  • HDAC7 suppression leads to abnormal histone acetylation, impacting reproductive function.
  • Targeting HDAC7 may offer a strategy to mitigate BPA's adverse effects on egg quality.