Progress and Future Direction of Chromosome-Centric Human Proteome Project

Area of Science:

• Proteomics
• Human Proteome Project
• Genomics

Background:

• This special issue commemorates the fifth anniversary of the Chromosome-Centric Human Proteome Project (C-HPP).
• It features 27 manuscripts covering metrics, missing protein detection, analytical methods, and protein functions in disease.
• The content primarily originates from C-HPP teams and the Biology and Disease-driven HPP.

Discussion:

• The C-HPP NeXt-MP50 Missing Proteins Challenge has reported 73 missing protein detections meeting HPP guidelines.
• Novel approaches were employed for these detections, showcasing advancements in proteomic analysis.
• Key messages from the contributing papers are summarized, offering insights into current research trends.

Key Insights:

• Significant progress in identifying and validating previously 'missing' proteins within the human proteome.
• Development and application of novel analytical methods for enhanced protein detection and quality assessment.
• Integration of proteomic data with functional and disease-related studies.

Outlook:

• Future directions for the C-HPP and broader human proteome research are discussed.
• Continued efforts to map the complete human proteome and understand protein functions.
• Potential for new discoveries in protein biology and disease mechanisms.