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Cell-Autonomous Metabolic Reprogramming in Hypoxia.

Luana Schito¹, Sergio Rey²

¹Biological Sciences, Sunnybrook Research Institute, Toronto, ON M4N 3M5, Canada.

Trends in Cell Biology

|December 2, 2017

Summary

This summary is machine-generated.

Hypoxia, or low oxygen, triggers significant metabolic adaptations in cells. This review details the molecular mechanisms driving these changes, crucial for understanding cellular fitness in health and disease.

Keywords:

HIF UPR epigenetics hypoxia mTOR metabolism

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Area of Science:

Cellular Biology
Metabolism
Biochemistry

Background:

Molecular oxygen (O2) is essential for ATP synthesis via mitochondrial respiration in metazoans.
Hypoxia (low O2) profoundly influences cellular evolution, metabolism, and (patho)biology.
Cells exhibit diverse metabolic adaptations to hypoxia, involving multiple regulatory levels.

Purpose of the Study:

To review cell-autonomous molecular mechanisms of hypoxic metabolic reprogramming.
To highlight adaptations in both health and disease contexts.
To provide an overview of current and emerging knowledge.

Main Methods:

Literature review of cell-autonomous mechanisms.
Analysis of transcriptional, translational, post-translational, and epigenetic responses.
Synthesis of findings related to metabolic reprogramming under hypoxia.

Main Results:

Hypoxia induces a wide array of metabolic adaptations.
These adaptations involve complex regulatory networks.
Cell-autonomous mechanisms are key drivers of metabolic reprogramming.

Conclusions:

Understanding hypoxic metabolic reprogramming is critical for health and disease.
Cell-autonomous responses are central to cellular adaptation to low oxygen.
Further research into these mechanisms can reveal therapeutic targets.