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Related Concept Videos

Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

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Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
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Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats
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A Practical Guide for Fractional Flow Reserve Guided Revascularisation.

Abdul Rahman Ihdayhid1, Andy Yong2, Richard Harper1

  • 1Monash Cardiovascular Research Centre, Monash University and MonashHeart, Monash Health, Melbourne, Vic, Australia.

Heart, Lung & Circulation
|December 2, 2017
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Summary

Fractional Flow Reserve (FFR) assesses myocardial ischaemia, guiding revascularisation for stable coronary artery disease. FFR-guided treatment improves outcomes and lowers costs compared to angiography alone.

Keywords:
Coronary artery diseaseFractional flow reserveFunctional assessmentPercutaneous coronary intervention

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Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Physiology

Background:

  • Myocardial ischaemia significantly impacts prognosis and revascularisation benefit in stable coronary artery disease.
  • Fractional Flow Reserve (FFR) is the established reference standard for invasive ischaemia assessment.
  • FFR identifies lesion-specific ischaemia, applicable across diverse patient and lesion types.

Purpose of the Study:

  • To review the fundamental principles of FFR.
  • To provide practical guidance for FFR-guided revascularisation.
  • To discuss the emerging role of non-hyperaemic indices in ischaemia assessment.

Main Methods:

  • Review of existing literature and clinical guidelines on FFR.
  • Analysis of FFR's diagnostic capabilities and clinical utility.
  • Exploration of non-hyperaemic indices as potential alternatives or adjuncts to FFR.

Main Results:

  • FFR-guided revascularisation demonstrates improved clinical outcomes.
  • FFR-guided interventions lead to reduced healthcare costs compared to angiography alone.
  • Emerging non-hyperaemic indices show promise in assessing ischaemia.

Conclusions:

  • FFR is a crucial tool for guiding revascularisation in stable coronary artery disease.
  • FFR-guided strategies offer both clinical and economic advantages.
  • Further research into non-hyperaemic indices is warranted.