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CT Features of Hepatic Veno-occlusive Disease: A Meta-analysis

Song Yang1, Jing Wu1, Si Lei2

  • 1Department of Radiology, The Second XiangYa Hospital, Central South University, Changsha, Hunan 410011, China.

Academic Radiology
|December 2, 2017
PubMed

Insights

Computed tomography (CT) scans can aid in diagnosing hepatic veno-occlusive disease (HVOD). Key CT findings include heterogeneous hypoattenuation and patchy enhancement, suggesting HVOD.

Area of Science:

  • Radiology
  • Hepatology
  • Medical Imaging

Background:

  • Hepatic veno-occlusive disease (HVOD) is a serious complication of hematopoietic stem cell transplantation and chemotherapy.
  • Accurate diagnosis of HVOD is crucial for timely management and improved patient outcomes.
  • Computed tomography (CT) is a widely available imaging modality that may reveal characteristic features of HVOD.

Purpose of the Study:

  • To perform a meta-analysis of existing studies on the computed tomography (CT) features of hepatic veno-occlusive disease (HVOD).
  • To identify the most significant CT findings associated with HVOD for diagnostic purposes.

Main Methods:

  • A systematic literature search was conducted in major electronic databases up to May 3, 2017.
  • Data on the proportion of various CT features in patients diagnosed with HVOD were extracted from included studies.
  • A meta-analysis was performed using R software (version 3.3.3) with the "meta" package.

Main Results:

  • Eleven studies comprising 326 patients were included in the meta-analysis.
  • The pooled proportion of key CT features included: heterogeneous hypoattenuation of hepatic parenchyma (81.05%), patchy enhancement in the portal venous phase (87.09%), and gallbladder wall edema (65.51%).
  • Narrowing or invisibility of hepatic veins was observed in 71.02% of cases, and patchy heterogeneous enhancement in the arterial phase was noted in 44.36%.

Conclusions:

  • Hepatic parenchyma with heterogeneous hypoattenuation is a significant CT finding in HVOD.
  • Patchy enhancement in the portal venous or equilibrium phase, with or without hepatic vein abnormalities, may be the most crucial CT feature for diagnosing HVOD.
Abstract

Keywords:
CTHSOSHVODacute stagemeta-analysispyrrolizidine alkaloid

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