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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Simple epithelium consists of a single layer of cells that lines body cavities and blood vessels. The shape of the cells in the epithelium reflects the function of the tissue. Cells in simple squamous epithelium appear as thin scales with flat, elliptical nuclei that mirror the form of the cell.
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Cells of the Epidermis01:24

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The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
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Dermis
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Primary cutaneous mucoepidermal carcinoma.

Mudita Gupta1, Anchana Gulati2, Kuldeep Verma1

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BMJ Case Reports
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PubMed
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Primary cutaneous mucoepidermal carcinoma (MEC) is rare. This report details a case in an elderly woman with a nasal lesion, confirmed via histopathology and immunohistochemistry.

Keywords:
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Area of Science:

  • Oncology
  • Dermatopathology
  • Head and Neck Cancer

Background:

  • Mucoepidermal carcinoma (MEC) typically originates in salivary glands.
  • Primary cutaneous MEC, a rare variant, presents a diagnostic challenge.
  • Understanding rare tumor presentations is crucial for accurate diagnosis and treatment.

Observation:

  • A 98-year-old woman presented with a noduloulcerative lesion on the nose.
  • The lesion was clinically suspected to be a skin malignancy.
  • This presentation is unusual for mucoepidermal carcinoma.

Findings:

  • Histopathology revealed nests of epidermoid cells with glandular differentiation and mucin production.
  • Immunohistochemistry confirmed the diagnosis of mucoepidermal carcinoma.
  • The tumor exhibited features of both mucus-secreting and epidermoid cells.

Implications:

  • This case highlights the importance of considering rare diagnoses in cutaneous lesions.
  • Accurate histopathological and immunohistochemical evaluation is vital for diagnosing primary cutaneous MEC.
  • Further research into the behavior and management of primary cutaneous MEC is warranted.