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Emerging data on improving response to hormone therapy: the role of novel targeted agents

Neelima Vidula1, Hope S Rugo2

  • 1a Division of Hematology and Oncology , Massachusetts General Hospital , Boston , MA , USA.

Expert Review of Anticancer Therapy
|December 2, 2017
PubMed
Abstract

Insights

Hormone resistance in HR+ breast cancer can be overcome with novel therapies targeting pathways like PI3K/AKT/mTOR and CDK 4/6. These emerging treatments offer improved responses for advanced and early-stage disease.

Area of Science:

  • Oncology
  • Endocrinology
  • Genomics

Background:

  • Hormone receptor-positive (HR+) breast cancer is the most common subtype.
  • Metastatic HR+ breast cancer often develops resistance to standard hormone therapies.
  • Resistance mechanisms include genomic alterations and pathway dysregulation.

Purpose of the Study:

  • To review strategies for overcoming hormone resistance in HR+ breast cancer.
  • To discuss pre-clinical and clinical perspectives on hormone resistance.
  • To highlight emerging novel therapies for HR+ breast cancer.

Main Methods:

  • Literature review of pre-clinical and clinical studies.
  • Discussion of targeted inhibition pathways: PI3K/AKT/mTOR, CDK 4/6, histone deacetylation, FGFR, and immune pathways.

Main Results:

  • Several novel therapies are approved or in development to enhance hormone therapy response.
  • CDK 4/6 and mTOR inhibitors show significant promise.
  • These agents are used in advanced stages and are being studied for early-stage disease.

Conclusions:

  • Targeted therapies offer new hope for overcoming hormone resistance in HR+ breast cancer.
  • CDK 4/6 and mTOR inhibitors are leading the way in advanced and early-stage treatment.
  • Continued research into novel pathways is crucial for improving patient outcomes.
Keywords:
CDK 4/6 inhibitorsPI3K/AKT/mTOR inhibitorsfibroblast growth factor receptor inhibitorshistone deacetylation inhibitorshormone receptor positive breast cancerhormone resistance

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