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Polymorphisms associated with adalimumab and infliximab response in moderate-to-severe plaque psoriasis
María C Ovejero-Benito1, Rocío Prieto-Pérez1, Mar Llamas-Velasco2
1Department of Clinical Pharmacology, Hospital Universitario de la Princesa, Instituto Teófilo Hernando, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria la Princesa (IIS-IP), E28006, Madrid, Spain.
Aim:
This study evaluated the influence of pharmacogenetics in psoriatic patients treated with adalimumab and/or infliximab.
Materials & Methods:
Prospective observational study evaluating the association of 124 polymorphisms with the response to adalimumab or infliximab (PASI75) in patients with moderate-to-severe plaque psoriasis at 3 months (n = 95) and 6 months of treatment (n = 90). Significant SNPs for univariate analysis were subjected to multivariate analysis.
Results:
Five SNPs were associated with PASI75 at 3 months: rs6661932 (IVL), rs2546890 (IL-12B), rs2145623 (NFKBIA), rs9304742 (ZNF816A) and rs645544 (SLC9A8). Furthermore, rs1061624 (TNFR1B) was associated with PASI75 at 6 months.
Conclusion:
Nevertheless, these biomarkers should be validated in large-scale studies before implementation in clinical practice.
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