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Updated: Feb 17, 2026

Author Spotlight: Advanced Single-Molecule Techniques for Investigating Telomeric Protein-DNA Interactions
Published on: August 30, 2024
TRFH domain: at the root of telomere protein evolution?
Marie-Joseph Giraud-Panis1, Jing Ye2, Eric Gilson1,2,3
1Université Côte d'Azur, CNRS UMR7284; Inserm U1081, Institute for Research on Cancer and Aging, Nice (IRCAN), Nice 06107, France.
Abstract:
Two articles in Cell Research focus on the structure-function relationships in the shelterin complex that binds to telomeres and is essential for their stability and functions. These studies concerning both mammalian and Schizosaccharomyces pombe proteins reveal unexpected structural conservation of a motif called TRFH (Telomeric Repeat Factors Homology) domain between several subunits in these complexes, providing a rationale for further dissection of the role of telomeres in chromosome stability, aging and cancer, and encouraging us to revisit the evolution of telomere proteins.
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