Related Experiment Video
Updated: Aug 16, 2026

High-throughput Assay to Phenotype Salmonella enterica Typhimurium Association, Invasion, and Replication in Macrophages
Published on: August 11, 2014
Epithelial cell surfaces induce Salmonella proteins required for bacterial adherence and invasion
B B Finlay1, F Heffron, S Falkow
1Department of Medical Microbiology, Stanford University School of Medicine, CA 94305.
Abstract:
Salmonella bacteria are capable of entering (invading) and multiplying within eukaryotic cells. Stable adherence to and invasion of epithelial cells by S. choleraesuis and S. typhimurium were found to require de novo synthesis of several new bacterial proteins. This inducible event appears to be a coordinately regulated system dependent on trypsin- and neuraminidase-sensitive structures present on the epithelial cell surface. Mutants of S. choleraesuis and S. typhimurium were unable to synthesize these proteins and did not stably adhere to nor invade eukaryotic cells. Two such S. typhimurium mutants were avirulent in mice, an indication that these proteins are required for Salmonella virulence.
Related Concept Videos
Adherens Junctions
Adherens Junctions are Dynamic
The endothelial cells...
Selectins
Outer Layers of the Cell Envelope
Colonisation of Pathogens
Determinants of Bacterial Pathogenicity and Virulence
Bacterial Gastroenteritis

