Management of antiplatelet therapy in patients undergoing neuroendovascular procedures

Area of Science:

• Neurology
• Cardiology
• Pharmacology

Background:

• Neuroendovascular techniques are standard for cerebrovascular conditions.
• Devices like stents and coils necessitate antiplatelet therapy.
• Variable patient responses to aspirin and clopidogrel pose clinical challenges.

Purpose of the Study:

• To review literature on antiplatelet use in neuroendovascular procedures.
• To provide recommendations for managing variable antiplatelet responses.
• To focus on clopidogrel's pharmacodynamic variability.

Main Methods:

• Literature review of antiplatelet therapy in neuroendovascular interventions.
• Analysis of pharmacodynamic responses to aspirin and clopidogrel.
• Synthesis of clinical recommendations based on existing evidence.

Main Results:

• Antiplatelet therapy is essential but exhibits significant inter-individual variability.
• Clopidogrel response variability complicates treatment optimization.
• Current literature highlights the need for personalized antiplatelet strategies.

Conclusions:

• Clinicians must address variable antiplatelet responses in neuroendovascular patients.
• Personalized antiplatelet selection, especially for clopidogrel, is critical.
• Further research may refine antiplatelet management protocols for neuroendovascular care.