[Aripiprazole-Induced Hyperhidrosis: Two Case Reports].

Area of Science:

• Pharmacology
• Clinical Neurology
• Psychiatry

Background:

• Drug-induced hyperhidrosis is a recognized adverse effect, often linked to medications impacting thermoregulatory pathways.
• Antipsychotics and antidepressants are frequently implicated in causing excessive sweating, potentially affecting patient adherence.
• The precise mechanisms involve drug interactions with the hypothalamus, spinal thermoregulatory centers, sympathetic ganglia, or the eccrine-neuroeffector junction.

Observation:

• Two female patients developed significant hyperhidrosis during treatment with aripiprazole.
• The hyperhidrosis symptoms resolved completely after the discontinuation of aripiprazole in both cases.
• This observation suggests a potential causal link between aripiprazole and the onset of hyperhidrosis.

Findings:

• Aripiprazole, an atypical antipsychotic, may induce hyperhidrosis as an adverse effect.
• The reported cases represent the first documented instances of aripiprazole-induced hyperhidrosis in medical literature.
• Resolution of symptoms upon drug cessation supports a direct relationship.

Implications:

• Clinicians should consider aripiprazole as a potential cause of hyperhidrosis in patients presenting with this symptom.
• Awareness of this adverse effect can improve patient management and medication adherence.
• Further research is warranted to elucidate the specific pharmacologic mechanisms underlying aripiprazole-induced hyperhidrosis.