Related Experiment Video
Updated: Feb 17, 2026

Assessment of Antibody-based Drugs Effects on Murine Bone Marrow and Peritoneal Macrophage Activation
Published on: December 26, 2017
Intravenous immunoglobulin-induced acute thrombocytopenia
Anna Gurevich-Shapiro1,2,3, Lilach Bonstein4, Galia Spectre2,3
1Internal Medicine H, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Background:
Intravenous immunoglobulin (IVIG) has known efficacy in various hematologic conditions, including immune thrombocytopenic purpura.
Study Design And Methods:
We present the clinical course of a patient with splenic marginal zone lymphoma, who developed acute thrombocytopenia on three consecutive episodes, with nadir counts of 27 × 109 , 50 × 109 , and 9 × 109 /L, upon administration of Intratect IVIG for hypogammaglobulinemia. An immunofluorescence test applying flow cytometry and monoclonal antibody immobilization of platelet antigens (MAIPA) assay were used to evaluate the reaction between IgG present in the IVIG preparations and the patient's or healthy donors' platelets (PLTs).
Results:
A strong direct binding reaction was observed between the patient's PLTs and Intratect IgG using both methods. A similar reaction failed to materialize with controls. Binding was not antigen specific according to MAIPA.
Conclusions:
This is the first reported case of thrombocytopenia as a possible adverse effect of IVIG.
Related Concept Videos
Venous Thrombosis III: Interprofessional Care
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Blood Transfusion and Agglutination
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Acute Kidney Injury III: Clinical Manifestations
Acute Kidney Injury I: Introduction
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

