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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Prevalence and predictors of peripheral neuropathy in nondiabetic children with chronic kidney disease
Sangeetha Yoganathan1, Arvind Bagga1, Sheffali Gulati1
1Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, 110029, India.
Insights
Peripheral neuropathy affects over half of children with chronic kidney disease (CKD). Risk factors include older age, low copper levels, and dialysis, highlighting the need for early detection in pediatric CKD patients.
Area of Science:
- Pediatric Nephrology
- Neurology
- Clinical Diagnostics
Background:
- Chronic kidney disease (CKD) in children can lead to various complications.
- Peripheral neuropathy is a potential complication, but its prevalence and predictors in nondiabetic pediatric CKD are not well-established.
Purpose of the Study:
- To determine the prevalence of peripheral neuropathy in nondiabetic children with CKD stages IV and V.
- To identify predictors and risk factors associated with peripheral neuropathy in this pediatric population.
Main Methods:
- A cohort of 51 nondiabetic children (3-18 years) with CKD stages IV-V was enrolled.
- Nerve conduction studies were performed on 50 children.
- Blood samples were analyzed for biochemical parameters, trace elements, and micronutrients.
Main Results:
- The prevalence of peripheral neuropathy was 52% in the study cohort.
- Axonal neuropathy (80.8%) was more common than demyelinating neuropathy (11.5%).
- Older age, low serum copper, and dialysis therapy were significant risk factors for peripheral neuropathy.
Conclusions:
- Peripheral neuropathy is highly prevalent in children with nondiabetic CKD.
- Electrodiagnostic studies are recommended for early assessment and management of peripheral neuropathy in pediatric CKD.
- Identifying risk factors like low copper and dialysis can help optimize care.
Introduction:
This study sought to determine the prevalence and predictors of peripheral neuropathy in nondiabetic children with chronic kidney disease (CKD).
Methods:
Fifty-one consecutive normally nourished children, 3-18 years of age, with CKD stages IV and V of nondiabetic etiology were enrolled from May to December 2012. Nerve conduction studies were performed in 50 children. Blood samples were analyzed for the biochemical parameters, trace elements, and micronutrients.
Results:
The prevalence of peripheral neuropathy in our cohort was 52% (95% confidence interval 37.65, 66.34). The majority (80.8%) of the children had axonal neuropathy, and 11.5% had demyelinating neuropathy. Isolated motor neuropathy was identified in 92.3% of the children, and sensorimotor neuropathy was identified in 7.6%. The significant risk factors associated with peripheral neuropathy were older age, low serum copper, and dialysis therapy.
Discussion:
Electrodiagnostic studies should be performed in children with CKD to assess for peripheral neuropathy for the purpose of optimizing medical care. Muscle Nerve 57: 792-798, 2018.
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