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Related Experiment Video

Updated: Feb 17, 2026

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics

Published on: May 11, 2016

Granular cell basal cell carcinoma: A case report.

Xinyi Ma¹, Guihua Wang², Aditya Kuwadekar³

¹Department of Pathology, Hang Zhou Dian Medical Laboratory, Hang Zhou, ZheJiang Province, P. R. China.

Journal of Cutaneous Pathology

|December 2, 2017

Summary

Granular cell basal cell carcinoma (BCC) is a rare BCC variant. This case report details a unique granular cell BCC presentation and its immunohistochemical profile.

Keywords:

Ber-EP4 basal cell carcimoma granular cell tumor skin carcinoma

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Area of Science:

Dermatopathology
Oncology

Background:

Basal cell carcinoma (BCC) is the most common human cancer.
Granular cell BCC is a rare histopathological variant with limited literature.

Observation:

A 47-year-old man presented with an ulceration on his right upper lip.
The lesion was surgically removed and examined histopathologically.

Findings:

The tumor consisted exclusively of granular cells with eosinophilic inclusions.
High mitotic activity (8-15/hpf) and a Ki-67 index of ~5% were noted.
Immunohistochemistry revealed positivity for Ber-EP4, pan-cytokeratin, AE1/AE3, CK5/6, p63, lysozyme, CD68, and Bcl-2.

Implications:

This case expands the understanding of granular cell BCC morphology and immunophenotype.
Further research may clarify the origin and behavior of this rare BCC variant.