Related Experiment Video
Updated: Feb 17, 2026

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
Published on: October 16, 2021
Repeated MitraClip procedure in patients with recurrent MR after a successful first procedure: Limitations and
Jonathan Curio1, Markus Reinthaler1,2, Mario Kasner1
1Department of Cardiology, Campus Benjamin Franklin, Charité Berlin, Berlin, Germany.
Objectives:
The present study aimed to evaluate the outcome and potential limitations of a repeated MitraClip procedure (ReClip).
Background:
The MitraClip procedure has emerged as a treatment option in high surgical risk patients suffering from severe mitral regurgitation (MR). However, despite successful initial repair a significant number of patients develops severe recurrent MR.
Methods:
Patients undergoing a ReClip procedure in our institution were retrospectively identified. Baseline data and the procedural outcome were assessed to identify potential limitations of such procedures.
Results:
Fifteen out of 234 patients undergoing a mitral-valve repair with the MitraClip device (Abbott Vascular) underwent a ReClip due to recurrent MR. In 11 patients, a MR reduction of at least one degree without causing mitral valve stenosis (trans-mitral mean gradient ≥5 mmHg) was achieved by performing a ReClip. After 1 year, two patients developed severe recurrent MR again. Pulmonary artery pressures significantly decreased after the procedure in individuals with successful repair (MR reduction of at least one degree and mitral valve mean gradient <5 mmHg).
Conclusion:
A ReClip procedure may be feasible in patients with recurrent MR but the risk benefit ratio should be carefully balanced against other treatment options.
Insights
A repeated MitraClip (ReClip) procedure can be effective for treating recurrent severe mitral regurgitation (MR) in select patients. Careful consideration of the risk-benefit balance is crucial when evaluating this option.
Area of Science:
- Cardiology
- Interventional Cardiology
- Medical Devices
Background:
- The MitraClip device offers a treatment for severe mitral regurgitation (MR) in high-risk surgical patients.
- Recurrent severe MR can occur despite initial successful MitraClip repair.
Purpose of the Study:
- To assess the outcomes and limitations of repeated MitraClip (ReClip) procedures for severe recurrent MR.
Main Methods:
- Retrospective analysis of patients who underwent a ReClip procedure.
- Evaluation of baseline data and procedural outcomes to identify limitations.
Main Results:
- 15 of 234 patients underwent ReClip for recurrent MR.
- 11 patients achieved MR reduction without significant mitral stenosis.
- Successful ReClip led to decreased pulmonary artery pressures.
Conclusions:
- ReClip is a feasible option for recurrent MR.
- Careful risk-benefit assessment is necessary compared to alternatives.
Related Concept Videos
Mitral Regurgitation III: Medical Management
Mitral Stenosis III: Medical Management
Mitral Regurgitation I: Introduction
Mitral Regurgitation II: Clinical Features and Diagnostic Tests
Mitral Regurgitation IV: Nursing Management
Mitral Valve Prolapse I: Introduction

