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CO2-Lasertonsillotomy Under Local Anesthesia in Adults
Published on: November 6, 2019
Tonsillectomy and risk of Parkinson's disease: A danish nationwide population-based cohort study
Elisabeth Svensson1,2, Victor W Henderson1,3,4, Szimonetta Szépligeti1
1Department of Clinical Epidemiology,Institute of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.
Background:
We hypothesized that tonsillectomy modifies the risk of PD.
Objectives:
To test the hypothesis in a nationwide population-based cohort study.
Methods:
We used Danish medical registries to construct a cohort of all patients in Denmark with an operation code of tonsillectomy 1980-2010 (n = 195,169) and a matched age and sex general population comparison cohort (n = 975,845). Patients were followed until PD diagnosis, death, censoring, or end of follow-up 30 November 2013. Using Cox regression, we computed hazard ratios for PD and corresponding 95% confidence intervals, adjusting for age and sex by study design, and potential confounders.
Results:
We identified 100 and 568 patients diagnosed with PD among the tonsillectomy and general population comparison cohort, respectively, finding similar risks of PD (adjusted hazard ratio = 0.95 [95% confidence interval: 0.76-1.19]; for > 20 years' follow-up (adjusted hazard ratio = 0.96 [95% confidence interval: 0.64-1.41]).
Conclusion:
Tonsillectomy is not associated with risk of PD, especially early-onset PD. © 2017 International Parkinson and Movement Disorder Society.
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