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Euthyroid hyperthyroxinaemia due to endogenous antibodies to thyroxine and tri-iodothyronine. A case report
G P Mulligan1, J S Davidson, H Kaplan
1Department of Chemical Pathology, University of Cape Town.
South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
|February 18, 1989
Abstract:
A case of euthyroid hyperthyroxinaemia caused by auto-antibodies to thyroxine and tri-iodothyronine is presented. Gel filtration chromatography of the patient's serum showed increased binding of radio-labelled thyroxine analogue to a macromolecular component, which migrated in the gammaglobulin region on electrophoresis. Precipitation by protein A confirmed that this was an immunoglobulin. The importance of recognising this condition so that inappropriate therapy can be avoided is stressed.